Significance of bone marrow immunohistochemical analysis in patients with plasma cell neoplasms

Background. The group of plasma cell neoplasms includes benign and malignant diseases. Sometimes there are difficulties in making a diagnosis. study the diagnostic prognostic significance immunohistochemical (IHC) markers is current interest. Aim. To IHC histological features bone marrow primary diagnosis patients with multiple myeloma (MM) monoclonal gammopathy undetermined (MGUS). Materials methods. included 287 neoplasms: MGUS ( n = 148), MM 139). observation period was 50 months. All have performed an aspiration biopsy examination analysis CD138 + , CD56 CD34 κ- λ-chains expression. Results. During progression to recorded 8.8 % 13) cases, determined 38.1 53) cases. In percentage cells at somewhat lower than p >0.001). Statistically significant differences were between groups by type infiltration р <0.001). With increase lesions (<20 vs. 20–50 >50 %), our interstitial diffuse lesion large accumulations more common compared nodular 0.001). expression 10 associated decrease progression-free survival MGUS. over osteodestructive syndrome detected X-ray methods 82.9 Determination immunoglobulin light chains indicated unfavorable prognosis. Resistance chemotherapy or disease most often occurred combination IgG secretion, according IHC, cells. progressed frequently 20 accumulation lesion, secretion two immunoglobulins. Conclusion. confirmed. Markers resistance identified.